Betnovate Cream

Betnovate Cream (Betamethasone Valerate Cream) - Product Information

Betnovate cream (Betamethasone Valerate) is used to treat a variety of skin conditions (e.g., eczema, dermatitis, allergies, rash). Betamethasone cream reduces the swelling, itching, and redness that can occur in these types of conditions.

Betnovate Cream is manufactured by GlaxoSmithKline Pharmaceuticals Limited, India in the strengths of 0.10% W/W and is available as a 20 gm tube. We also have in stock Fluorouracil Topical Cream (Flonida Cream) which is used for the topical treatment of multiple actinic or solar keratoses of the face, ears, and anterior scalp.

Name of the Drug

We supply original Betnovate cream manufactured by GlaxoSmithKline Pharmaceuticals Limited, India.

Manufacturer of Betnovate Cream

GlaxoSmithKline Pharmaceuticals Limited  
Website: www.gsk-india.com

Active Ingredient present in Betnovate Cream

The active ingredient present in Betnovate Cream is Betamethasone Valerate. Each gram of the cream contains contains 1.2 mg Betamethasone Valerate (equivalent to 1 mg Betamethasone) in a soft, white, hydrophilic cream of water, mineral oil, white Petrolatum, Polyethylene Glycol 1000 Monocetyl Ether, Cetostearyl Alcohol, Monobasic Sodium Phosphate and Phosphoric acid or Sodium Hydroxide; Chlorocresol is present as a preservative.

Uses of Betnovate Cream

Betamethasone valerate (Betnovate Cream) is a potent topical corticosteroid indicated for adults, elderly and children over 1 year for the relief of the inflammatory and pruritic manifestations of steroid responsive dermatoses. These indications include the following:

• Atopic dermatitis (including infantile atopic dermatitis)
• Nummular dermatitis (discoid eczema)
• Prurigo nodularis
• Psoriasis (excluding widespread plaque psoriasis)
• Lichen simplex chronicus (neurodermatitis) and lichen planus
• Seborrhoeic dermatitis
• Irritant or allergic contact dermatitis
• Discoid lupus erythematosus
• Adjunct to systemic steroid therapy in generalised erythroderma
• Insect bite reactions

Betnovate Cream works by reducing the inflammation in the affected area to reduce the redness, swelling and itchiness of the skin.

Betnovate Cream (Betamethasone Valerate) - Dosage

Wash and dry your hands before using. Clean and dry the affected area. Apply a thin film of medication to the affected area and gently rub in, usually 1 to 3 times daily or as directed by your doctor.

Do not bandage, cover, or wrap the area unless directed to do so by your doctor. If used in the diaper area on an infant, do not use tight-fitting diapers or plastic pants.

Use Betnovate cream on the skin only. However, do not use it on the face, groin, or underarms unless directed to do so by your doctor. In case the condition worsens or does not improve within 2 to 4 weeks, treatment and diagnosis should be re-evaluated.

Betnovate Cream Storage

Store Betnovate Cream at controlled room temperature 20°C to 25°C (68°F to 77°F). Protect from light. Protect from freezing. Do not leave it in the car or on windowsills. Keep your medicine where young children cannot reach it.

Betnovate Cream Contraindications

Betnovate cream is contraindicated in patients with a hypersensitivity to Betamethasone Valerate or any inactive ingredient present in Betnovate cream. Betnovate cream is also contraindicated in patients with a hypersensitivity to any other similar medicines such as other corticosteroids.

The following conditions should not be treated with Betamethasone Valerate cream: Untreated cutaneous infections, Rosacea, Acne vulgaris, Pruritus without inflammation, Perianal and genital pruritus and Perioral dermatitis.
Betnovate cream is contraindicated in dermatoses in infants under one year of age, including dermatitis
Some of the symptoms of an allergic reaction to this medicine may include:

• shortness of breath
• wheezing or difficulty breathing
• swelling of the face, lips, tongue or other parts of the body
• rash, itching or hives on the skin

Betamethasone Valerate Cream - Warnings and Precautions

Systemic absorption of topical corticosteroids like Betamethasone Valerate Cream has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in certain patients.
Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings.
Therefore, patients receiving a large dose of a potent topical steroid applied to a large surface area should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests.
In case HPA axis suppression is noted, an attempt should be made to withdraw the medicine, to reduce the frequency of application, or to substitute a less potent steroid. Recovery of HPA axis function is generally prompt and complete upon discontinuation of the medicine.

Children may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity.

In case irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted.

In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent must be instituted. If a favorable response does not occur soon, the corticosteroid should be discontinued until the infection has been adequately controlled.

In infants and children under 12 years of age, treatment courses should be limited to five days and occlusion should not be used; long-term continuous topical corticosteroid therapy should be avoided where possible, as adrenal suppression can occur.

Bacterial infection is encouraged by the warm, moist conditions within skin folds or caused by occlusive dressings. When using occlusive dressings, the skin should be cleansed before a fresh dressing is applied.

Topical corticosteroids should be used with caution in psoriasis as rebound relapses, development of tolerances, risk of generalised pustular psoriasis and development of local or systemic toxicity due to impaired barrier function of the skin have been reported in some cases. If used in psoriasis careful patient supervision is important.

Prolonged application to the face is undesirable as this area is more susceptible to atrophic changes; therefore, treatment courses should be limited to five days and occlusion should not be used.

If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye, as cataract and glaucoma might result from repeated exposure.

Visual disturbance may be reported with systemic and topical corticosteroid use. If a patient presents with symptoms such as blurred vision or other visual disturbances, the patient should be considered for referral to an ophthalmologist for evaluation of possible causes which may include cataract, glaucoma or rare diseases such as central serous chorioretinopathy (CSCR) which have been reported after use of systemic and topical corticosteroids.

Appropriate antimicrobial therapy should be used whenever treating inflammatory lesions which have become infected. Any spread of infection requires withdrawal of topical corticosteroid therapy and administration of appropriate antimicrobial therapy.

Topical corticosteroids are sometimes used to treat the dermatitis around chronic leg ulcers. However, this use may be associated with a higher occurrence of local hypersensitivity reactions and an increased risk of local infection.

Betnovate contains Chlorocresol which may cause allergic reactions and cetostearyl alcohol which may cause local skin reactions (e.g. contact dermatitis).

Betnovate Cream Side Effects

The most commonly reported Betnovate cream side effect is local irritation which includes itching, burning,dryness, and redness.
Inform your doctor immediately if you notice any of the following at the application site of the medicine:

• thinning of the skin with easy bruising
• rash around the mouth area
• stretch marks or streaks on the skin
• infection of the hair roots
• change in skin colour
• increased hair growth
• heat rash
• acne

Side effects are more frequent if Betnovate cream is used under dressings that are close-fitting and keep out the air. Long periods of treatment under close-fitting dressings may cause thinning of the skin.
If large areas of the skin are treated, especially for a long time and under tight dressings, some steroid may be absorbed into the body. This may cause various effects including:

• stomach ulcers
• high blood pressure
• delayed wound healing
• increased chance of infection
• excessive growth of facial and body hair
• acne
• increased body fluid
• muscle weakness

If you have any questions about any of these effects, you should speak to your doctor immediately.

If you think you are having an allergic reaction to your medicine, inform your doctor immediately or go to the accident and emergency centre at your nearest hospital. Symptoms may include: wheezing, swelling of the eyelids, face, lips and mouth, lumpy rash ("hives”),  tightness in the chest and fainting.

This is not a complete list of all possible Betnovate cream side effects.

Betnovate Cream Overdosage

Topically applied corticosteroids like Betnovate cream can be absorbed in sufficient amounts to produce systemic effects. Acute overdosage is very unlikely to occur, however, in the case of chronic overdosage or misuse the features of hypercortisolism could occur.

In the case of overdose, Betamethasone Valerate should be withdrawn gradually by reducing the frequency of application, or by substituting a less potent corticosteroid because of the risk of glucocorticosteroid insufficiency.

Betnovate Cream During Pregnancy

Betamethasone Valerate (Betnovate Cream) has been classified by the US FDA as Pregnancy Category C. Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals.

There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids can be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Nursing Considerations

It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk.

Systemically administered corticosteroids are secreted into breast milk in quantities not likely to have a deleterious effect on the infant. Topical administration should be avoided on the nipple or any area where the infant could directly ingest the drug from the skin.

Nevertheless, caution should be exercised when topical corticosteroids are administered to a nursing woman. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Buy Betnovate Cream Online at Only $2.20 per Tube

You can buy Betamethasone Valerate Cream online from Clear Sky Pharmacy at a cheap price. Betnovate Cream 0.10%, manufactured by GlaxoSmithKline Pharmaceuticals Limited, India are supplied in a tube of 20 gm. The 20 gm tube cost only $2.20 per unit when you place an order for 50 tubes.

Disclaimer

The above information is provided to the best of our knowledge and in good faith, it is without a warrant of any kind, expressed or implied.

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